Director of Facilities, Laboratory Operations and EHS

Director of Facilities, Laboratory Operations and EHS
Компания: Olema Oncology
Город: San Francisco
Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. With our transformation into a fully integrated oncology company well underway, it’s an exciting time to be part of Team Olema.
Our lead product candidate, palazestrant, is a novel, orally available complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently in two pivotal Phase 3 clinical trials. We expect top-line data from OPERA-01, our ongoing Phase 3 trial of palazestrant as a monotherapy in patients with second- or third-line ER+/HER2- metastatic breast cancer (MBC), in Q1 2027 which, if positive, could lead to our first potential approval and commercial launch in 2028. OPERA-02, our Phase 3 trial of palazestrant in combination with ribociblib in patients with frontline ER+/HER2- MBC, is enrolling patients. Together with its mechanism of action, pharmacokinetic properties, and the potential to demonstrate activity in both ESR1 wild-type and mutant tumors, palazestrant could transform the metastatic breast cancer treatment paradigm and provide access to a $15 billion global market opportunity.
Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with the potential to generate further value and meaningfully impact the metastatic breast cancer treatment landscape – particularly in combination with palazestrant. We recently presented encouraging Phase 1 monotherapy data from this program across multiple solid tumor types, are advancing patient enrollment in the ongoing combination arms in MBC, and expect to initiate a Phase 1 study of OP-3136 in combination with Bayer’s darolutamide in metastatic castration-resistant prostate cancer by the end of this year.
Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and passionate colleagues dedicated to helping the patients we serve feel better, longer. Team Olema possesses a deep commitment to a shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, the drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution. We are a small group of nimble self-starters who bring consistency in our quest for the extraordinary every single day.
If you’re ready to be part of a tenacious, courageous, agile, and growing team, join us in making a profound impact, together – for our patients, for your career, and for what’s beyond.
**About the Role >>> Director of Facilities, Laboratory Operations and EHS**
As the Director of Facilities, Laboratory Operations and EHS reporting to the Chief Legal Officer, you will be responsible for the strategic leadership, operational excellence, and long-term planning of Olema’s facilities and laboratory environments across multiple sites. In this role you will own the full lifecycle of facilities and lab operations, from day-to-day execution to large-scale initiatives including laboratory buildouts, office and lab relocations. The Director, Facilities, Laboratory Operations & EHS will oversee three Olema locations, including BSL2 laboratory environments and corporate office space, and serves as a senior partner to Research, IT, Real Estate, Finance, and Executive Leadership.
This role is based in our San Francisco office and will require 15% travel
Your work will _primarily_ encompass:
**Facilities, Real Estate & Capital Execution:**
* Responsible for the day-to-day facility operations, upkeep, and maintenance of a multi-site business
* Lead and execute all facilities operations and physical infrastructure activities across Olema’s locations
* Own the execution of Real Estate strategy, including site readiness, lease transitions, expansions, consolidations, and exits
* Lead office and laboratory moves and building relocations, with full accountability for planning, execution, risk management, and stabilization
* Direct laboratory and office buildouts end-to-end, from programming and design through permitting, construction, commissioning, and occupancy
* Execute capital projects in active lab environments while maintaining safety, compliance, and continuity of scientific operations
* Develop and enforce facilities standards, policies, procedures, and SOPs
* Own physical security programs, including access control, badging, alarms, vendor oversight, and incident response
* Control facilities operating and capital budgets, including forecasting, spend management, and cost accountability
* Lead emergency planning and response across all facilities
* Direct shipping and receiving operations, including Hazardous Materials and Dangerous Goods compliance
* Own all workplace services across all locations, including office supplies, beverage and food programs, janitorial services, and waste management, with accountability for vendor performance, cost control, and service quality
**Laboratory Operations:**
* Support the research team with all infrastructure needs, including vendor relationships and management, service and maintenance of scientific equipment, hazardous waste management, and cell culture support
* Monitor critical systems and provide 24-hour on-call support in case of system failure
* Develop and maintain awareness of health and safety issues within the company, ensure compliance with company policies through appropriate training of employees, and manage safety consultants effectively.
* Experience managing sample inventories and vendors.
* Manage and Maintain Cryo storage, liquid nitrogen, compressed gas system, emergency generator system, vacuum and compressed air systems
* Manage critical laboratory systems, including but not limited to HVAC, monitoring, systems and equipment maintenance, to ensure uninterrupted functionality and optimal performance.
* Oversee all aspects of shipping and receiving operations, including inventory management, packaging, and transportation logistics, to facilitate efficient and timely movement of goods.
* Lead and execute laboratory operations to ensure uninterrupted, compliant research support.
**Environmental Health & Safety (EHS) Ownership:**
* Accountable owner of Olema’s Environmental Health and Safety program
* Design, implement, enforce, and continuously improve EHS policies, procedures, training, and compliance programs
* Lead all regulatory inspections, audits, and agency interactions
* Own hazardous waste permitting, reporting, corrective actions, and compliance documentation
* Embed EHS requirements into lab design, construction, moves, and daily operations
* Direct EHS consultants and contractors with clear accountability for outcomes
* Maintain, train and scale EHS programs supporting BSL-2 laboratory environments
_Knowledge:_
* Bachelor’s Degree required
* Strategic Facilities Manager (SFM) and Certified Safety Professional (CSP) certifications preferred
* Proven track record of successful facilities leadership experience
* Expert-level knowledge of facilities, laboratory operations, and EHS in biotech or life sciences
* Strong project management, planning, organization, and time management skills
_Experience:_
* Minimum of 12 years of experience with a minimum of 5 years of facilities management experience, including oversight of lab environments
* Created and ran an EHS program for a BSL2 Lab a must have
* Demonstrated ownership of lab buildouts relocations, and real estate execution
* Hands on facilities, lab operations, and leadership experience who can move seamlessly between strategic planning and tactical execution, particularly in challenging laboratory settings that require sound judgment, calm decision-making, and rigorous operational discipline
* Demonstrated experience and ability working in a dem