Senior Scientist, Max Perutz Labs

Senior Scientist, Max Perutz Labs
Компания: University of Vienna
Город: Vienna
At the University of Vienna, almost 11,000 people work together on the big questions of the future. Approximately 7,700 of them are academic staff members. These are individuals who, with their curiosity and their continuous pursuit of excellence, engage in international cutting-edge research and teaching. With us, you will also find space to unfold your potential. We are looking for a/an ... **Senior Scientist** **74 Max Perutz Labs** **Startdate:** 11.01.2027 | **Working hours:** 40 | **Collective bargaining agreement:** * 48 VwGr. B1 lit. b (postdoc) Reference no.: 6381 Explore and teach at the University of Vienna, where over 7,500 brilliant minds have found a unique balance of freedom and support. Join us if you’re passionate about groundbreaking international research and academic excellence. Ready to be part of our team? Let’s shape the future together! The Max Perutz Labs bring together the groups working in molecular biology at the University of Vienna. In order to intensify the collaboration with the Medical University of Vienna in the field of molecular biosciences, the Max Perutz Labs were founded in 2005. We maintain high-tech research infrastructures at two neighbouring locations, where around 450 scientists from more than 40 nations work in basic biomedical research in more than 45 research groups. **Your Personal Sphere Of Play** The Matos laboratory is looking for a highly motivated and experienced Senior Scientist with strong expertise in DNA repair, protein biochemistry and biochemical reconstitution, ideally complemented by experience in structural biology. The Matos lab is an internationally competitive and collaborative research group investigating the molecular mechanisms that control meiotic chromosome organization and homologous recombination. We are particularly interested in understanding how recombination intermediates are formed and processed, how meiotic crossovers are generated, and how chromosome architecture and recombination are coordinated to ensure accurate chromosome segregation during gametogenesis. To address these questions, we combine genetics, molecular and cell biology, biochemistry, genomics, structural approaches and advanced imaging in budding yeast and mammalian experimental systems. The successful candidate will take a leading scientific role in the laboratory, developing and conducting mechanistic research projects in the areas of DNA repair, homologous recombination and chromosome biology. A major focus will be on the biochemical and molecular mechanisms of DNA repair and recombination proteins and protein complexes, including their purification, functional characterization and reconstitution in vitro. Experience with structural approaches to understand the organization and regulation of protein and protein–DNA complexes is highly desirable. We are looking for an experienced scientist who combines deep technical expertise with broad scientific curiosity and who enjoys developing new approaches to answer challenging biological questions. Importantly, the successful candidate should not be defined by a single methodology or research question. Research directions in the laboratory evolve as new biological insights, technologies and opportunities emerge. We are therefore particularly looking for someone who can adapt to new scientific developments, learn and establish new methodologies, critically evaluate emerging technologies, and redirect experimental strategies when unexpected findings open new avenues of research. In addition to their own research, the Senior Scientist will contribute to the scientific development of other members of the laboratory, including the supervision and training of undergraduate, Master and PhD students. The position also includes teaching and a limited contribution to laboratory organization and management. **Your Future Tasks** * The successful candidate will actively participate in research, teaching and supervision and will take a leading role in the scientific development of projects within the laboratory. * A central responsibility will be to develop and conduct mechanistic research projects addressing fundamental questions in DNA repair, homologous recombination, meiotic crossover formation and chromosome biology. The Senior Scientist will independently plan, execute and interpret experiments and contribute intellectually to the development of new research directions within the group. * A major component of the position will involve protein biochemistry and biochemical reconstitution. This includes the expression and purification of recombinant proteins and multi-protein complexes, development of quantitative biochemical assays, reconstitution of molecular reactions in vitro, and analysis of protein–protein and protein–DNA interactions. The successful candidate will use these approaches to dissect the molecular mechanisms, regulation and organization of DNA repair and recombination machineries. * Depending on expertise and research questions, the Senior Scientist will also contribute structural approaches to the study of protein and protein–DNA complexes. Experience in structural biology, including cryo-electron microscopy, X-ray crystallography or related approaches, is therefore particularly valuable. The position provides opportunities to integrate biochemical and structural approaches with genetics, cell biology, advanced microscopy, proteomics and genome-wide methodologies available within the laboratory and the wider Vienna BioCenter environment. * An important expectation of the position is the ability to adapt experimental strategies as projects develop. The Senior Scientist will be encouraged to identify and establish new methodologies when required to address emerging biological questions, to critically assess technological developments in the field, and to follow unexpected findings when these suggest important new research directions. The aim is not simply to apply established techniques, but to identify the most appropriate experimental approaches for answering the biological question at hand. * The Senior Scientist will contribute broad scientific and technical expertise to projects across the laboratory. This includes discussing experimental strategies, helping with troubleshooting and data interpretation, developing or optimizing experimental workflows, and transferring expertise between projects and laboratory members. * The successful candidate will contribute to scientific publications, presentations, collaborative projects and grant-related activities and will present research findings at national and international scientific meetings. * The position also includes practical and theoretical teaching of undergraduate and graduate students in molecular biology, biochemistry, genetics and chromosome biology. The Senior Scientist will supervise and mentor Bachelor and Master students and contribute to the scientific and practical supervision of PhD students and other junior researchers. * While this is primarily a scientific position, the successful candidate will also contribute to selected aspects of laboratory organization. This may include coordination and maintenance of specialized biochemical or structural biology workflows and equipment, development and documentation of protocols, training of laboratory members in specialized techniques, and contribution to laboratory safety and good scientific practice. * Together with the group leader and other senior members of the laboratory, the Senior Scientist will contribute to maintaining a rigorous, collaborative, supportive and scientifically ambitious research environment. **This Is Part Of Your Personality** * PhD degree in biochemistry, molecular biology, structural biology, genetics, cell biology or a related field. * Strong scientific background in DNA repair, homologous recombination, chromosome biology or related